Across TCGA patient cohorts, RPF2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPF2-associated genes across cancer lineages are ER-alpha, STAT3_pY705, and AR. Each is linked with RPF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPF2-to-partner and partner-to-RPF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPF2→partner) and Y-score (partner→RPF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	-1.035	-3.321	.016	.010	3	1
UCEC	STAT3_pY705 →	-0.557	-3.321	<.001	.010	2	2
UCEC	AR →	-0.430	-3.321	.028	.010	3	1
UCEC	MEK1 →	+0.600	+3.321	.001	.010	1	1
UCEC	VHL →	-1.319	-3.321	<.001	.010	1	1
UCEC	Cyclin-B1 →	+0.794	+3.321	.006	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

RPF2 survival (RNA) · tumor vs normal (RNA) · all RPF2 data types