RPF1

Across TCGA pan-cancer cohorts, RPF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RPF1 data layer compared with 30 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RPF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RPF1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where RPF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.876	0.504	.002	31	view →
CCRCC	DFS	Tertile	III,IV	0.544	0.887	.011	26	view →
LUAD	DFS	Median	III,IV	0.931	0.584	.021	11	view →
HNSC	DFS	Median	III,IV	0.367	0.854	.044	2	view →
PDAC	OS	Median	III,IV	0.991	0.616	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RPF1–LSCC (DFS)

Open the LSCC breakdown →