RPF1

Across TCGA patient cohorts, RPF1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPF1-associated genes across cancer lineages are p27_pT198, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with RPF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPF1-to-partner and partner-to-RPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by RPF1-low versus RPF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPF1→partner) and Y-score (partner→RPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.104	+3.321	.018	.010	3	2
UCEC	A-Raf_pS299 →	-0.180	-3.459	<.001	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.144	-2.575	.005	.010	3	1
UCEC	JNK2 →	+0.253	+3.000	.002	.001	3	1
UCEC	Ku80 →	+0.244	+2.335	.012	.003	3	1
UCEC	MEK1 →	+0.355	+2.321	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

p27_pT198 by RPF1 expression — UCEC

Explore this box plot interactively →