RPEL1

Across TCGA patient cohorts, RPEL1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPEL1-associated genes across cancer lineages are INPP4B, eEF2, and eIF4E. Each is linked with RPEL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPEL1-to-partner and partner-to-RPEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by RPEL1-low versus RPEL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPEL1→partner) and Y-score (partner→RPEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.361	-3.321	.008	.009	3	2
UCEC	eEF2 →	+0.308	+1.700	.042	.044	3	1
UCEC	eIF4E →	+0.188	+3.584	.035	.002	3	1
UCEC	eIF4G →	+0.280	+1.700	.033	.044	3	1
UCEC	G6PD →	-0.308	-2.301	.025	.034	3	1
UCEC	JNK2 →	+0.312	+4.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

INPP4B by RPEL1 expression — UCEC

Explore this box plot interactively →