Across TCGA pan-cancer cohorts, RPE mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RPE data layer compared with 24 for mass-spec protein and 2 for mutation status.
The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RPE mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RPE expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.
LUAD, LSCC, and HNSC are the cancer types where RPE mass-spec protein most reproducibly stratifies survival.
mass-spec protein survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.