Across TCGA patient cohorts, RPE protein abundance is significantly associated with the RNA expression of many other genes, with 8,026 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible RPE-associated genes across cancer lineages are CDK12, SLC35G1, and KIF11. Each is linked with RPE in more than 2 cancer types. Because this analysis shows association rather than direction, both RPE-to-partner and partner-to-RPE results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPE→partner) and Y-score (partner→RPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CDK12 →	-0.375	-0.228	<.001	<.001	3	3
LSCC	SLC35G1 →	-0.892	-0.214	<.001	<.001	3	3
HNSC	KIF11 →	-0.567	-0.170	.004	.007	3	3
LSCC	DNAJC7 →	-0.212	-0.198	.004	<.001	3	3
LSCC	PARPBP →	-0.565	-0.223	.001	<.001	3	3
LUAD	UROS →	-0.307	-0.173	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,026 associations by consensus.

Exploration

RPE survival (RNA) · tumor vs normal (RNA) · all RPE data types