RPARP-AS1

Across TCGA pan-cancer cohorts, RPARP-AS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RPARP-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RPARP-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPARP-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and MESO show a favorable association.

ACC, BLCA, and MESO are the cancer types where RPARP-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.192	0.713	<.001	73	view →
BLCA	OS	Quartile	All	0.725	0.508	<.001	62	view →
MESO	OS	Median	All	0.481	0.278	.001	61	view →
BRCA	OS	Median	III,IV	0.731	0.289	<.001	54	view →
PAAD	DFS	Tertile	All	0.457	0.166	.001	48	view →
LGG	DFS	Median	All	0.541	0.330	<.001	48	view →
LUAD	OS	Tertile	All	0.874	0.759	<.001	36	view →
UCS	OS	Median	All	0.472	0.283	.012	24	view →
HNSC	DFS	Quartile	IV	0.713	0.362	.007	23	view →
LIHC	DFS	Median	All	0.425	0.611	.012	17	view →
SARC	OS	Median	All	0.716	0.480	.013	13	view →
LAML	DFS	Tertile	All	0.159	0.484	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RPARP-AS1–ACC (DFS)

Open the ACC breakdown →