RPAP2

Across TCGA cell cohorts, RPAP2 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RPAP2-associated genes across cancer lineages are GAGE12J, KRTAP10-3, and FTHL17. Each is linked with RPAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPAP2-to-partner and partner-to-RPAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12J grouped by RPAP2-low versus RPAP2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPAP2→partner) and Y-score (partner→RPAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
OVARY	KRTAP10-3 →	+0.027	+4.807	<.001	.003	3	1
LUNG_NSCLC_LUAD	FTHL17 →	+2.187	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	RGR →	+0.020	+4.481	<.001	.001	3	1
LUNG_NSCLC_LUAD	OCSTAMP →	+0.011	+4.343	<.001	.002	3	1
LUNG_NSCLC_LUAD	CLEC4D →	+0.084	+4.093	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

GAGE12J by RPAP2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →