RPAP1

Across TCGA cell cohorts, RPAP1 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPAP1-associated genes across cancer lineages are HCRTR1, AQP12A, and MORN5. Each is linked with RPAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPAP1-to-partner and partner-to-RPAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HCRTR1 grouped by RPAP1-low versus RPAP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPAP1→partner) and Y-score (partner→RPAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HCRTR1 →	+0.124	+3.554	.002	.005	3	2
BLOOD_Leukemia	AQP12A →	+0.079	+3.269	<.001	.007	3	1
BLOOD_Leukemia	MORN5 →	+0.228	+3.177	<.001	.004	3	1
BLOOD_Leukemia	VWC2 →	+0.351	+3.381	<.001	.002	3	1
BLOOD_Leukemia	CGB5 →	+0.056	+3.239	<.001	.004	3	1
BLOOD_Leukemia	GPRIN2 →	+0.029	+3.004	<.001	.007	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

HCRTR1 by RPAP1 expression — BLOOD_Leukemia

Explore this box plot interactively →