RPAIN

Across TCGA patient cohorts, RPAIN protein abundance is significantly associated with the RNA expression of many other genes, with 7,994 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RPAIN-associated genes across cancer lineages are FXR2, TTC19, and METTL16. Each is linked with RPAIN in more than 5 cancer types. Because this analysis shows association rather than direction, both RPAIN-to-partner and partner-to-RPAIN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RPAIN versus FXR2 in LSCC, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPAIN→partner) and Y-score (partner→RPAIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FXR2 →	+0.544	+0.449	<.001	<.001	3	6
BRCA	TTC19 →	+0.751	+0.577	<.001	<.001	3	5
BRCA	METTL16 →	+0.581	+0.530	<.001	<.001	3	5
CCRCC	MED11 →	+0.322	+0.388	.003	.002	3	5
BRCA	CENPV →	+1.177	+0.562	<.001	<.001	3	5
HNSC	ELP5 →	+0.468	+0.317	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,994 associations by consensus.

RPAIN vs FXR2 — LSCC

Explore this scatter interactively →