RPAIN

Across TCGA patient cohorts, RPAIN mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPAIN-associated genes across cancer lineages are GSK-3a-b_pS21_S9, MSH2, and Rab25. Each is linked with RPAIN in more than 1 cancer types. Because this analysis shows association rather than direction, both RPAIN-to-partner and partner-to-RPAIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by RPAIN-low versus RPAIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPAIN→partner) and Y-score (partner→RPAIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.494	+2.817	.035	.036	3	1
UCEC	MSH2 →	-0.336	-2.973	.007	.035	3	1
UCEC	Rab25 →	-0.458	-3.169	.011	.020	3	1
UCEC	S6_pS240_S244 →	+0.596	+3.169	.007	.020	3	1
UCEC	Tuberin →	+0.433	+3.009	.003	.019	3	1
UCEC	ERK2 →	+0.269	+3.169	.011	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GSK-3a-b_pS21_S9 by RPAIN expression — UCEC

Explore this box plot interactively →