RPA2

Across TCGA patient cohorts, RPA2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPA2-associated genes across cancer lineages are eEF2, JNK_pT183_Y185, and JNK2. Each is linked with RPA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPA2-to-partner and partner-to-RPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RPA2-low versus RPA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPA2→partner) and Y-score (partner→RPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.549	+3.000	.005	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.271	-3.000	.003	.036	3	1
UCEC	JNK2 →	+0.313	+2.817	.004	.036	3	1
UCEC	mTOR_pS2448 →	-0.257	-3.169	.001	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.853	-3.156	<.001	.020	3	1
UCEC	p70-S6K_pT389 →	-0.282	-3.169	.006	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eEF2 by RPA2 expression — UCEC

Explore this box plot interactively →