RPA2

Across TCGA cell cohorts, RPA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,092 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RPA2-associated GO terms across cancer lineages are Spindle elongation, Negative regulation of mitotic metaphase/anaphase transition, and Mitotic spindle midzone assembly. Each is linked with RPA2 in more than 18 cancer types. Because this analysis shows association rather than direction, both RPA2-to-partner and partner-to-RPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by RPA2-low versus RPA2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPA2→partner) and Y-score (partner→RPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Spindle elongation →	+0.252	+1.021	<.001	<.001	3	19
LIVER	Negative regulation of mitotic metaphase/anaphase transition →	+0.156	+1.054	.001	<.001	3	18
SOFT_TISSUE	Mitotic spindle midzone assembly →	+0.215	+0.799	<.001	<.001	3	18
SOFT_TISSUE	Positive regulation of chromosome segregation →	+0.176	+0.830	<.001	<.001	3	18
SOFT_TISSUE	Regulation of chromosome condensation →	+0.222	+0.754	<.001	.002	3	18
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.170	+1.180	<.001	.002	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,092 associations by consensus.

Spindle elongation by RPA2 expression — BLOOD_Myeloma

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