RPA1

Across TCGA patient cohorts, RPA1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPA1-associated genes across cancer lineages are 4E-BP1, RAD51, and Bad_pS112. Each is linked with RPA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RPA1-to-partner and partner-to-RPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by RPA1-low versus RPA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPA1→partner) and Y-score (partner→RPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.483	+2.614	<.001	.005	2	4
UCEC	RAD51 →	+0.169	+3.321	.002	.010	3	2
UCEC	Bad_pS112 →	-0.197	-2.308	.008	.033	3	2
UCEC	CDK1 →	+0.165	+2.183	.006	.033	3	2
COAD	Caspase-7-cleavedD198 →	+1.040	+3.178	.007	.010	1	4
UCEC	HER3_pY1289 →	+0.105	+3.341	.002	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

4E-BP1 by RPA1 expression — UCEC

Explore this box plot interactively →