RPA1

Across TCGA cell cohorts, RPA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,043 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RPA1-associated GO terms across cancer lineages are Mitotic sister chromatid segregation, Chromosome segregation, and Sister chromatid segregation. Each is linked with RPA1 in more than 16 cancer types. Because this analysis shows association rather than direction, both RPA1-to-partner and partner-to-RPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic sister chromatid segregation grouped by RPA1-low versus RPA1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPA1→partner) and Y-score (partner→RPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Mitotic sister chromatid segregation →	+0.094	+1.107	<.001	<.001	3	17
BLOOD_Lymphoma	Chromosome segregation →	+0.086	+1.031	<.001	<.001	3	17
OVARY	Sister chromatid segregation →	+0.094	+0.975	<.001	.001	3	17
OVARY	Nuclear chromosome segregation →	+0.085	+0.970	.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Metaphase chromosome alignment →	+0.109	+0.753	.004	.006	3	17
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.269	+1.120	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,043 associations by consensus.

Mitotic sister chromatid segregation by RPA1 expression — OVARY

Explore this box plot interactively →