RPA1

Across TCGA cell cohorts, RPA1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPA1-associated genes across cancer lineages are C20orf85, AMELX, and IL22. Each is linked with RPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPA1-to-partner and partner-to-RPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by RPA1-low versus RPA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPA1→partner) and Y-score (partner→RPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1
BLOOD_Leukemia	AMELX →	+0.039	+5.124	<.001	<.001	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1
BLOOD_Leukemia	CST2 →	+0.572	+4.567	<.001	.001	3	1
BLOOD_Leukemia	GSTA3 →	+0.017	+4.384	<.001	.006	3	1
BLOOD_Leukemia	OR11H6 →	+0.022	+3.705	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

C20orf85 by RPA1 expression — BLOOD_Leukemia

Explore this box plot interactively →