RP2

Across TCGA patient cohorts, RP2 mutation is significantly associated with the RNA expression of many other genes, with 6,555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RP2-associated genes across cancer lineages are RNA5SP24, MTND4LP19, and SCEL-AS1. Each is linked with RP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RP2-to-partner and partner-to-RP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP24 grouped by RP2-low versus RP2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RP2→partner) and Y-score (partner→RP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP24 →	+0.337	+7.731	<.001	.009	3	2
UCEC	MTND4LP19 →	+0.104	+2.348	.001	.001	3	2
SKCM	SCEL-AS1 →	+0.069	+4.680	<.001	.007	3	2
BRCA	MIR320B1 →	+0.391	+7.731	<.001	.009	3	2
BRCA	RN7SL673P →	+0.154	+8.055	<.001	.007	3	1
SKCM	RNU6-1194P →	+0.524	+5.118	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,555 associations by consensus.

RNA5SP24 by RP2 expression — BRCA

Explore this box plot interactively →