RP2

Across TCGA patient cohorts, RP2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RP2-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4G. Each is linked with RP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RP2-to-partner and partner-to-RP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RP2-low versus RP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RP2→partner) and Y-score (partner→RP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.076	-1.780	.018	.024	3	1
UCEC	EGFR_pY1068 →	-0.245	-2.058	.002	<.001	3	1
UCEC	eIF4G →	+0.232	+1.523	.019	.008	3	1
UCEC	ERK2 →	+0.154	+1.584	.012	.017	3	1
UCEC	FoxM1 →	+0.232	+2.058	.004	<.001	3	1
UCEC	G6PD →	-0.211	-1.571	.041	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

14-3-3_beta by RP2 expression — UCEC

Explore this box plot interactively →