RORC

Across TCGA cell cohorts, RORC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,191 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible RORC-associated GO terms across cancer lineages are Negative regulation of NK T cell activation, Regulation of tolerance induction dependent upon immune response, and Antigen processing and presentation of exogenous peptide antigen via MHC class I. Each is linked with RORC in more than 9 cancer types. Because this analysis shows association rather than direction, both RORC-to-partner and partner-to-RORC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of NK T cell activation grouped by RORC-low versus RORC-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RORC→partner) and Y-score (partner→RORC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of NK T cell activation →	+0.487	+1.492	.001	.001	3	10
LIVER	Regulation of tolerance induction dependent upon immune response →	+1.278	+1.683	.008	.007	3	9
LUNG_SCLC	Antigen processing and presentation of exogenous peptide antigen via MHC class I →	+0.145	+1.008	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Cellular response to ketone →	+0.093	+1.920	<.001	<.001	3	8
BREAST	Positive regulation of amyloid precursor protein catabolic process →	+0.100	+1.616	.009	.003	3	8
LUNG_SCLC	tRNA wobble uridine modification →	-0.060	-0.857	.003	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,191 associations by consensus.

Negative regulation of NK T cell activation by RORC expression — BLOOD_Lymphoma

Explore this box plot interactively →