RORC

Across TCGA cell cohorts, RORC mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RORC-associated genes across cancer lineages are PITX3, HTR1B, and COX6A2. Each is linked with RORC in more than 1 cancer types. Because this analysis shows association rather than direction, both RORC-to-partner and partner-to-RORC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PITX3 grouped by RORC-low versus RORC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RORC→partner) and Y-score (partner→RORC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PITX3 →	+0.189	+3.643	<.001	.005	3	1
LARGE_INTESTINE	HTR1B →	+0.062	+3.351	<.001	.002	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ENPP6 →	+0.029	+3.115	.006	.004	3	1
LARGE_INTESTINE	OR2K2 →	+0.019	+2.925	.008	.007	3	1
LARGE_INTESTINE	ELOA3DP →	+0.022	+3.103	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

PITX3 by RORC expression — LARGE_INTESTINE

Explore this box plot interactively →