Across TCGA pan-cancer cohorts, RORB Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RORB data layer compared with 25 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher RORB Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RORB expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, UCEC, and SKCM are the cancer types where RORB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.514	0.963	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.933	0.429	.009	28	view →
SKCM	OS	Median	All	0.399	0.783	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RORB tumor-vs-normal RNA expression · all RORB data types