RORB

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RORB mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RORB-associated genes across cancer lineages are eIF4E, PDCD4, and PKC-b-II_pS660. Each is linked with RORB in more than 1 cancer types. Because this analysis shows association rather than direction, both RORB-to-partner and partner-to-RORB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RORB→partner) and Y-score (partner→RORB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECeIF4E →+0.187+1.662.012.01132
UCECPDCD4 →-0.646-2.392<.001<.00132
COADPKC-b-II_pS660 →-0.477-3.000.009.03532
UCECRictor_pT1135 →-0.097-2.584.007.01032
UCECSTAT3_pY705 →-0.569-3.523<.001<.00132
UCECASNS →+0.424+1.700<.001.04232
Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Exploration