Across TCGA cell cohorts, RORB mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RORB-associated genes across cancer lineages are MAGEB4, RFPL3, and OR6Q1. Each is linked with RORB in more than 1 cancer types. Because this analysis shows association rather than direction, both RORB-to-partner and partner-to-RORB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RORB→partner) and Y-score (partner→RORB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	RFPL3 →	+0.040	+4.095	.001	.009	3	1
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP4-4 →	+0.013	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	REG1B →	+0.274	+4.169	<.001	.002	3	1
BLOOD_Lymphoma	OR2M7 →	+0.044	+4.662	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

RORB survival (RNA) · tumor vs normal (RNA) · all RORB data types