RORA

Across TCGA patient cohorts, RORA mutation is significantly associated with the RNA expression of many other genes, with 2,916 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RORA-associated genes across cancer lineages are GNL3, MAD2L1, and GRPEL2. Each is linked with RORA in more than 2 cancer types. Because this analysis shows association rather than direction, both RORA-to-partner and partner-to-RORA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNL3 grouped by RORA-low versus RORA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RORA→partner) and Y-score (partner→RORA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNL3 →	+0.401	+2.510	.004	.001	3	3
UCEC	MAD2L1 →	+0.640	+3.721	.002	<.001	3	3
SKCM	GRPEL2 →	+0.671	+3.350	.005	.005	3	3
UCEC	NEMP1 →	+0.628	+3.087	<.001	<.001	3	3
UCEC	CKAP2L →	+0.616	+3.024	.001	<.001	3	3
SKCM	CCNE2 →	+0.802	+3.341	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,916 associations by consensus.

GNL3 by RORA expression — UCEC

Explore this box plot interactively →