RORA

Across TCGA patient cohorts, RORA mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RORA-associated genes across cancer lineages are Rictor_pT1135, Shc_pY317, and c-Jun_pS73. Each is linked with RORA in more than 1 cancer types. Because this analysis shows association rather than direction, both RORA-to-partner and partner-to-RORA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by RORA-low versus RORA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RORA→partner) and Y-score (partner→RORA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.083	-1.906	.020	.015	3	2
UCEC	Shc_pY317 →	-0.132	-1.440	.012	.024	3	2
UCEC	c-Jun_pS73 →	-0.117	-1.986	.034	.029	3	2
UCEC	Cyclin-B1 →	+0.582	+2.070	.002	.001	3	2
SKCM	E-Cadherin →	-1.243	-3.000	.006	.034	3	1
UCEC	14-3-3_beta →	-0.078	-1.847	.024	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Rictor_pT1135 by RORA expression — UCEC

Explore this box plot interactively →