RORA

Across TCGA cell cohorts, RORA mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RORA-associated genes across cancer lineages are CABP5, UBQLN3, and KRTAP10-1. Each is linked with RORA in more than 1 cancer types. Because this analysis shows association rather than direction, both RORA-to-partner and partner-to-RORA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABP5 grouped by RORA-low versus RORA-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RORA→partner) and Y-score (partner→RORA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1
SKIN	UBQLN3 →	+0.016	+5.415	<.001	.004	3	1
SKIN	KRTAP10-1 →	+0.019	+4.977	<.001	.007	3	1
SKIN	PRSS58 →	+0.047	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CABP5 by RORA expression — BLOOD_Lymphoma

Explore this box plot interactively →