ROR2

Across TCGA pan-cancer cohorts, ROR2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ROR2 data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ROR2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ROR2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

COAD, LSCC, and PDAC are the cancer types where ROR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.863	1.000	.039	30	view →
LSCC	OS	Quartile	III,IV	0.263	0.901	.008	10	view →
PDAC	DFS	Quartile	All	0.284	0.513	.002	9	view →
GBM	OS	Quartile	All	0.308	0.642	.019	4	view →
CCRCC	DFS	Median	All	1.000	0.483	.034	4	view →
LUAD	DFS	Tertile	III,IV	0.899	0.448	.040	3	view →
HNSC	DFS	Median	IV	0.876	0.664	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ROR2–COAD (DFS)

Open the COAD breakdown →