Across TCGA pan-cancer cohorts, ROR1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ROR1 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ROR1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ROR1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ACC, UCEC, and COAD are the cancer types where ROR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
UCEC	DFS	Median	II,III,IV	0.928	0.437	.021	18	view →
COAD	DFS	Median	All	0.388	0.799	<.001	15	view →
BRCA	OS	Median	All	0.909	0.963	.029	4	view →
SKCM	DFS	Median	IV	1.000	0.201	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ROR1 tumor-vs-normal RNA expression · all ROR1 data types