Across TCGA pan-cancer cohorts, ROR1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ROR1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ROR1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ROR1 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and HNSC are the cancer types where ROR1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ROR1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−1.140	<.001	9	view →
LUAD	Female	All	−0.724	<.001	9	view →
HNSC	All	All	−0.630	.007	7	view →
CCRCC	Female	II,III,IV	−0.448	.031	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ROR1 RNA expression & survival · all ROR1 data types