Across TCGA patient cohorts, ROR1 mutation is significantly associated with the RNA expression of many other genes, with 3,431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROR1-associated genes across cancer lineages are RASSF1, NANOGP3, and UHRF1. Each is linked with ROR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ROR1-to-partner and partner-to-ROR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROR1→partner) and Y-score (partner→ROR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RASSF1 →	+0.316	+1.807	.001	<.001	3	4
LIHC	NANOGP3 →	+0.162	+4.690	.001	.003	3	3
UCEC	UHRF1 →	+0.731	+1.595	<.001	.001	3	3
UCEC	PKN3 →	+0.690	+2.332	<.001	<.001	3	3
UCEC	POC1A →	+0.478	+2.753	.002	<.001	3	3
UCEC	RPUSD4 →	+0.308	+3.828	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,431 associations by consensus.

Exploration

ROR1 survival (RNA) · tumor vs normal (RNA) · all ROR1 data types