Across TCGA cell cohorts, ROR1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ROR1-associated genes across cancer lineages are FCAR, RPS4Y2, and H2BW1. Each is linked with ROR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ROR1-to-partner and partner-to-ROR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROR1→partner) and Y-score (partner→ROR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FCAR →	+0.035	+4.472	<.001	.004	3	2
STOMACH	RPS4Y2 →	+0.020	+3.662	<.001	.001	3	2
CNS	H2BW1 →	+0.120	+5.285	<.001	<.001	3	1
CNS	HTR5A →	+0.038	+4.472	<.001	.004	3	1
CNS	H1-8 →	+0.022	+5.357	<.001	.001	3	1
CNS	CYP2A13 →	+0.022	+5.044	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

ROR1 survival (RNA) · tumor vs normal (RNA) · all ROR1 data types