ROGDI

Across TCGA patient cohorts, ROGDI mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROGDI-associated genes across cancer lineages are p38-MAPK_pT180_Y182, EGFR_pY1068, and eIF4G. Each is linked with ROGDI in more than 1 cancer types. Because this analysis shows association rather than direction, both ROGDI-to-partner and partner-to-ROGDI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by ROGDI-low versus ROGDI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROGDI→partner) and Y-score (partner→ROGDI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.450	-1.794	.015	.027	3	2
UCEC	EGFR_pY1068 →	-0.231	-2.321	.025	.006	3	1
UCEC	eIF4G →	+0.368	+3.321	.004	.009	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.457	+2.321	.029	.006	3	1
UCEC	p62 Lck ligand →	+0.412	+2.584	.002	.010	3	1
UCEC	Rab11 →	-0.128	-2.321	.032	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

p38-MAPK_pT180_Y182 by ROGDI expression — UCEC

Explore this box plot interactively →