ROGDI

Across TCGA cell cohorts, ROGDI mutation is significantly associated with the mutation status of many other genes, with 4,008 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ROGDI-associated genes across cancer lineages are ANGEL1, DDX49, and GRB10. Each is linked with ROGDI in more than 2 cancer types. Because this analysis shows association rather than direction, both ROGDI-to-partner and partner-to-ROGDI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANGEL1 grouped by ROGDI-low versus ROGDI-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROGDI→partner) and Y-score (partner→ROGDI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANGEL1 →	+4.196	+5.321	<.001	<.001	1	3
BLOOD_Leukemia	DDX49 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	GRB10 →	+4.000	+5.050	.008	.008	1	3
BLOOD_Leukemia	FEM1A →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	GJA1 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	PHAX →	+4.736	+5.560	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,008 associations by consensus.

ANGEL1 by ROGDI expression — LARGE_INTESTINE

Explore this box plot interactively →