ROCK1P1

Across TCGA patient cohorts, ROCK1P1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROCK1P1-associated genes across cancer lineages are ERK2, FoxM1, and GAPDH. Each is linked with ROCK1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ROCK1P1-to-partner and partner-to-ROCK1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ROCK1P1-low versus ROCK1P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROCK1P1→partner) and Y-score (partner→ROCK1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.310	+2.321	.001	.035	3	1
UCEC	FoxM1 →	+0.295	+3.459	.023	.005	3	1
UCEC	GAPDH →	+0.777	+3.459	.003	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.250	-2.999	.003	.035	3	1
UCEC	Ku80 →	+0.274	+3.009	.020	.019	3	1
UCEC	MAPK_pT202_Y204 →	-0.663	-3.169	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ERK2 by ROCK1P1 expression — UCEC

Explore this box plot interactively →