ROBO4

Across TCGA pan-cancer cohorts, ROBO4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ROBO4 data layer compared with 28 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ROBO4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ROBO4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, BLCA, and LUAD are the cancer types where ROBO4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.980	0.612	<.001	32	view →
BLCA	OS	Median	IV	0.092	0.605	<.001	24	view →
LUAD	OS	Median	II,III,IV	0.356	0.719	<.001	18	view →
LIHC	DFS	Median	All	0.186	0.557	.036	6	view →
STAD	DFS	Median	III,IV	1.000	0.328	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ROBO4–UCEC (DFS)

Open the UCEC breakdown →