ROBO4

Across TCGA patient cohorts, ROBO4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,748 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ROBO4-associated genes across cancer lineages are VWF, INMT, and GPIHBP1. Each is linked with ROBO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ROBO4-to-partner and partner-to-ROBO4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ROBO4 versus VWF in LUAD, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO4→partner) and Y-score (partner→ROBO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VWF →	+0.905	+0.483	<.001	<.001	3	3
LUAD	INMT →	+1.230	+0.371	.001	.002	3	3
BRCA	GPIHBP1 →	+1.346	+0.483	.001	.006	3	3
LUAD	RGCC →	+0.638	+0.321	.004	.009	3	2
LSCC	SOD3 →	+0.706	+0.358	.003	<.001	3	2
LSCC	FHL5 →	+0.709	+0.335	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,748 associations by consensus.

ROBO4 vs VWF — LUAD

Explore this scatter interactively →