ROBO4

Across TCGA patient cohorts, ROBO4 mutation is significantly associated with the RNA expression of many other genes, with 4,462 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROBO4-associated genes across cancer lineages are SLC25A27, SMIM10L2A, and TEDC1. Each is linked with ROBO4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ROBO4-to-partner and partner-to-ROBO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A27 grouped by ROBO4-low versus ROBO4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO4→partner) and Y-score (partner→ROBO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC25A27 →	-0.667	-3.574	.004	.002	3	4
UCEC	SMIM10L2A →	-0.421	-1.696	.003	<.001	3	4
COAD	TEDC1 →	+0.595	+2.906	<.001	.001	3	4
UCEC	PHF5A →	+0.448	+2.222	<.001	<.001	3	4
SKCM	KIF2C →	+0.700	+2.944	<.001	<.001	3	4
SKCM	POC1A →	+0.549	+3.858	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,462 associations by consensus.

SLC25A27 by ROBO4 expression — COAD

Explore this box plot interactively →