ROBO4

Across TCGA patient cohorts, ROBO4 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROBO4-associated genes across cancer lineages are Caspase-7-cleavedD198, HER2, and PR. Each is linked with ROBO4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ROBO4-to-partner and partner-to-ROBO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ROBO4-low versus ROBO4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO4→partner) and Y-score (partner→ROBO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.396	+1.662	.016	.009	3	4
LUSC	HER2 →	+0.303	+2.000	.018	.027	3	3
UCEC	PR →	-0.150	-1.584	.032	.032	3	3
SKCM	c-Kit →	-0.540	-2.321	.039	.032	3	3
UCEC	eEF2 →	+0.235	+1.280	.018	.049	3	3
LUSC	EGFR →	+0.335	+1.892	.017	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Caspase-7-cleavedD198 by ROBO4 expression — UCEC

Explore this box plot interactively →