ROBO4

Across TCGA cell cohorts, ROBO4 mutation is significantly associated with the RNA expression of many other genes, with 204 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ROBO4-associated genes across cancer lineages are AKAIN1, MAGEB4, and RBMY1J. Each is linked with ROBO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ROBO4-to-partner and partner-to-ROBO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKAIN1 grouped by ROBO4-low versus ROBO4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO4→partner) and Y-score (partner→ROBO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AKAIN1 →	+0.045	+3.345	.001	.007	3	2
LARGE_INTESTINE	MAGEB4 →	+0.008	+2.830	.001	.004	3	2
BLOOD_Leukemia	RBMY1J →	+0.093	+3.684	<.001	.004	3	2
SOFT_TISSUE	TGM6 →	+0.043	+5.977	<.001	.001	3	1
SKIN	USP29 →	+0.059	+3.510	<.001	.003	3	1
BLOOD_Lymphoma	CFC1 →	+0.879	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 204 associations by consensus.

AKAIN1 by ROBO4 expression — SKIN

Explore this box plot interactively →