Across TCGA pan-cancer cohorts, ROBO2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ROBO2 data layer compared with 28 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ROBO2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ROBO2 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, LUAD, and LSCC are the cancer types where ROBO2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.638	0.262	.006	18	view →
LUAD	DFS	Quartile	All	0.850	0.974	.041	1	view →
LSCC	DFS	Quartile	All	1.000	0.462	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ROBO2 tumor-vs-normal RNA expression · all ROBO2 data types