Across TCGA patient cohorts, ROBO2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROBO2-associated genes across cancer lineages are ERK2, Rb_pS807_S811, and Claudin-7. Each is linked with ROBO2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ROBO2-to-partner and partner-to-ROBO2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO2→partner) and Y-score (partner→ROBO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.153	+1.530	.002	.003	3	4
LUAD	Rb_pS807_S811 →	+0.374	+2.169	.002	.003	3	3
ESCA	Claudin-7 →	+0.613	+3.321	.040	.007	3	3
STAD	Smad1 →	+0.121	+3.459	.031	.004	3	3
ESCA	Chk1 →	+0.278	+2.041	.032	.045	3	3
LUSC	Shc_pY317 →	-0.171	-2.981	.018	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration

ROBO2 survival (RNA) · tumor vs normal (RNA) · all ROBO2 data types