ROBO1

Across TCGA pan-cancer cohorts, ROBO1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ROBO1 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ROBO1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ROBO1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where ROBO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.594	0.953	.001	31	view →
CCRCC	OS	Median	IV	1.000	0.314	.008	17	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ROBO1–HNSC (OS)

Open the HNSC breakdown →