ROBO1

Across TCGA patient cohorts, ROBO1 mutation is significantly associated with the total protein of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ROBO1-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and Cyclin-E2. Each is linked with ROBO1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ROBO1-to-partner and partner-to-ROBO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ROBO1-low versus ROBO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO1→partner) and Y-score (partner→ROBO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.468	+1.126	.001	.011	3	5
STAD	Cyclin-B1 →	+0.476	+2.906	.002	.001	3	4
COAD	Cyclin-E2 →	+0.242	+2.222	<.001	.008	3	4
COAD	beta-Catenin →	-0.683	-1.662	<.001	.009	3	4
COAD	GSK-3a-b_pS21_S9 →	-0.222	-1.389	.044	.041	3	4
LUSC	Src_pY527 →	-0.471	-2.450	.007	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

Caspase-7-cleavedD198 by ROBO1 expression — UCEC

Explore this box plot interactively →