ROBO1

Across TCGA cell cohorts, ROBO1 mutation is significantly associated with the RNA expression of many other genes, with 1,511 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ROBO1-associated genes across cancer lineages are GLTP, OXT, and PRND. Each is linked with ROBO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ROBO1-to-partner and partner-to-ROBO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLTP grouped by ROBO1-low versus ROBO1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ROBO1→partner) and Y-score (partner→ROBO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GLTP →	+0.485	+2.145	.007	.006	3	3
LUNG_NSCLC_LUSC	OXT →	+0.148	+3.584	.002	.003	3	2
BLOOD_Myeloma	PRND →	+0.049	+3.906	.003	.009	3	2
BLOOD_Leukemia	MRGPRD →	+0.346	+2.993	<.001	<.001	3	2
SKIN	PAIP2B →	+0.474	+3.212	.003	.006	3	2
SKIN	NPFFR1 →	+0.031	+3.559	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,511 associations by consensus.

GLTP by ROBO1 expression — BLOOD_Leukemia

Explore this box plot interactively →