RO60

Across TCGA pan-cancer cohorts, RO60 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RO60 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RO60 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RO60 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where RO60 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.556	0.806	.004	38	view →
UCEC	DFS	Tertile	III,IV	0.303	1.000	.017	24	view →
CCRCC	DFS	Tertile	III,IV	0.898	0.499	.006	16	view →
LSCC	DFS	Median	III,IV	0.412	0.910	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RO60–HNSC (OS)

Open the HNSC breakdown →