RO60

Across TCGA patient cohorts, RO60 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RO60-associated genes across cancer lineages are PRAS40_pT246, 14-3-3_beta, and eEF2. Each is linked with RO60 in more than 1 cancer types. Because this analysis shows association rather than direction, both RO60-to-partner and partner-to-RO60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by RO60-low versus RO60-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RO60→partner) and Y-score (partner→RO60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.191	+1.700	.002	.040	3	2
UCEC	14-3-3_beta →	-0.085	-2.295	.023	.033	3	1
UCEC	eEF2 →	+0.348	+2.321	.009	.034	3	1
UCEC	EGFR_pY1068 →	-0.221	-1.700	.018	.042	3	1
UCEC	A-Raf_pS299 →	-0.125	-2.321	.005	.033	3	1
UCEC	FOXO3a →	-0.092	-2.308	.016	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PRAS40_pT246 by RO60 expression — UCEC

Explore this box plot interactively →