RO60

Across TCGA cell cohorts, RO60 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RO60-associated genes across cancer lineages are GML, GPR26, and ZSWIM2. Each is linked with RO60 in more than 1 cancer types. Because this analysis shows association rather than direction, both RO60-to-partner and partner-to-RO60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by RO60-low versus RO60-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RO60→partner) and Y-score (partner→RO60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.070	+4.152	<.001	.009	3	1
BLOOD_Leukemia	GPR26 →	+0.057	+4.539	<.001	.007	3	1
BLOOD_Leukemia	ZSWIM2 →	+0.025	+4.409	.004	.005	3	1
BLOOD_Leukemia	CST2 →	+0.501	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR10Q1 →	+0.024	+4.969	<.001	.003	3	1
BLOOD_Leukemia	NPSR1 →	+0.041	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GML by RO60 expression — BLOOD_Leukemia

Explore this box plot interactively →