Across TCGA pan-cancer cohorts, RNY4P34 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RNY4P34’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where RNY4P34 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNY4P34 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
UCEC, KICH, and ESCA are the cancer types where RNY4P34 tumor–normal differential expression is most reproducible.