Across TCGA pan-cancer cohorts, RNVU1-34 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNVU1-34’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RNVU1-34 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNVU1-34 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BLCA, BRCA, and STAD are the cancer types where RNVU1-34 tumor–normal differential expression is most reproducible.