Across TCGA pan-cancer cohorts, RNU7-10P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU7-10P’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RNU7-10P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU7-10P is over-expressed in tumor.
BLCA and STAD are the cancer types where RNU7-10P tumor–normal differential expression is most reproducible.